At home, hardened police detective Aidan Breslin (Dennis Quaid) has grown increasingly distant from his two young sons Alex and Sean since the death of his wife. At work, he finds himself thrust into an investigation of perverse serial killings rooted in the Biblical prophecy of the Four Horsemen of the Apocalypse. As Breslin grapples with each new revelation in the case, he slowly discovers a shocking connection between himself and the four suspects.